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- W2376072938 abstract "Free radicals are known to be the major cause of various chronic and degenerative diseases,including aging,coronary heart disease,inflammation,stroke,diabetes mellitus and cancer.Reactive oxygen species(ROS),including free radicals such as superoxide anion radical(O-2 ·),hydrogen peroxide(H2O2) and hydroxyl radical(· HO),can cause cellular injuries and initiate peroxidation of polyunsaturated fatty acids in biological membranes.Moreover,it has been suggested that lipid peroxyl radicals contribute to the oxidation of lipids,increasing the risk of atherosclerosis,which is an awful disease of the artery wall for human.Isoflavones,the naturally occurring compounds,are capable of scavenging free radicals and inhibiting lipids oxidation in vivo,which possess potential cardioprotective effects.However,the poor solubility of these compounds limits their bioavailability in vivo.In order to improve the bioavailability,a novel antioxidant isoflavone derivative,5,7,4′-tri(hydroxyl)isoflavonyl-8-azophenylsulfonic acid(1) was designed and synthe-sized and its structure was characterized by IR,1H-NMR and elemental analysis.The scavenging activities of the title compound on hydroxyl radicals(· OH) were detected by fluorescent spectrophotometry,while its scavenging activities on superoxide anion free radicals(O-2 ·) and 1,1-diphenyl-2-picrylhydrazyl free radical(DPPH ·) were measured by ultraviolet spectrophotometry.The experimental results showed that the title compound could scavenge superoxide anion free radicals,DPPH · and hydroxyl radicals effectively with IC50 values of(11.88±0.1) μmol · L-1,(36.2±0.3) μmol · L-1 and(2.12±0.1) ×10-7 mol · L-1,respectively.The scavenging activity on hydroxyl radicals was better than that on superoxide anion free radicals and DPPH ·." @default.
- W2376072938 created "2016-06-24" @default.
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- W2376072938 date "2012-01-01" @default.
- W2376072938 modified "2023-09-23" @default.
- W2376072938 title "Synthesis and antioxidant activities of 5,7,4′-tri(hydroxyl) isoflavonyl-8-azophenylsulfonic acid" @default.
- W2376072938 hasPublicationYear "2012" @default.
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