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- W2376075327 abstract "Objective To analyze the changes of matrix metalloproteinases -8(MMP -8) levels in gingival crevicular fluid (GCF) after subgingivally administering 2%minocycline - HC1 ointment to the periodontal pocket as an auxiliary treatment of moderate and severe chronic periodontitis.Methods Twenty - six subjects were selected.The left and right sides of oral cavity were divided into control group and test group with a randomized single blind method.After initial periodontal treatment of both groups,the test group was treated with the sustained release unguent of minocycline - HCL ointment in the pocket once a week for 2 weeks,while the control group with 0.9%normal saline and 10%hydrogen peroxide.Two weeks later,gingival crevicular fluid samples were collected and detected with ELISA technique.Results The level of MMP -8 in GCF obviously declined after treatment in both groups(P0.01), particularly in the test group.The difference was statistically sigificant(P0.01 ).Conclusions Administration of the local drug system of 2%minocycline - HCL ointment as the auxiliary treatment of moderate and severe chronic periodontitis can reduce the levels of matrix metalloproteinases - 8 in GCF and improve the periodontal tissue conditions." @default.
- W2376075327 created "2016-06-24" @default.
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- W2376075327 date "2011-01-01" @default.
- W2376075327 modified "2023-09-25" @default.
- W2376075327 title "Effect of Minocycline Hydrochloride Ointment on MMP - 8 in Gingival Crevicular Fluid Abstract" @default.
- W2376075327 hasPublicationYear "2011" @default.
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