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- W2376087219 abstract "Objective:To investigate the phamacokinetics of vancomycin in continuous venovenous hemofiltration(CVVH) in order to determine appropriate vancomycin dosing strategies for patients receiving CVVH . Methods: The serum concentrations of vancomycin were measured by TDx and the pharmacokinetics parameters were calculated.Results:The pharmacokinetics of vancomycin during CVVH was fitted with open twocompartment model.At the beginning of CVVH,the pharmacokinetic parameters were:maximum plasma concentration (Cmax)=22 18 mg/L,minimum plasma concentration attained(Cmin)=5 82 mg/L,halflife of drug(T1/2)=5 75 h,apparent volume of distribution(Vd)=21 92 L,total body clearance of drug(CL)=3 49 L/h?On the 16 d of CVVH,the pharmacokinetic parameters were Cmax=38 70 mg/L,Cmin= 16 50 mg/L ,T1/2=33 32 h,Vd=12 92 L,CL=0 38 L/h. Conclusion:CVVH can significantly augment the clearance of vancomycin in acute renal failure patients.Dosing strategies for individualization of vancomycin therapy in patients receiving CVVH are proposed.Monitoring the serum concentration during CVVH is necessary." @default.
- W2376087219 created "2016-06-24" @default.
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- W2376087219 date "2003-01-01" @default.
- W2376087219 modified "2023-09-23" @default.
- W2376087219 title "Phamacokinetics of vancomycin in continuous veno-venous hemofiltration" @default.
- W2376087219 hasPublicationYear "2003" @default.
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