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- W2376090324 abstract "OBJECTIVE To investigate the influence of the serum with TCM for Bushen Huoxue(补肾活血)decoction on the glutamate up-take activity of Muller cells in high glucose.METHODS Muller cells of rat were cultured with modified enzyme-digesting method;The glutamate up-take activity of Muller cells was determined by intracellular[3H] labeled D,L-glutamate concentration.RESULTS The increases of glutamate up-take activity of Muller cells could be caused rapidly in high glucose.However,this increase was temporary,it would become a sharp decreasing with the time passing.The serum with TCM for bushenhuoxue decoction could enhance the glutamate up-take activity of Muller cells in normal control,meanwhile this effect afforded by that serum was the strongest at 24 hours.However,this effect afforded by that serum was the strongest at 48 hours in high glucose.CONCLUSIONS In short time,the enhancement of glycolysis in Muller cells produced by high glucose may be one of the mechanism of increases on glutamate up-take activity of Muller cells.Muller cells in culture may be resistant to high glucose,however persistent high glucose could result in injury of Muller cells.The serum with TCM Bushen Huoxue decoction could relieve the damages of glutamate up-take activity of Muller cells in high glucose,accordingly it may be one of the important mechanisms of Bushen Huoxue therapy could prevent and cure diabetic retinopathy." @default.
- W2376090324 created "2016-06-24" @default.
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- W2376090324 date "2008-01-01" @default.
- W2376090324 modified "2023-09-24" @default.
- W2376090324 title "Effect of Bushen Huoxue(补肾活血)therapy on the glutamate up-take activity of Müller cell" @default.
- W2376090324 hasPublicationYear "2008" @default.
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