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- W2376095264 abstract "Objective To investigate the expression of VEGF-A and VEGFR-1,in 50 cases of endometrial carcinomas and to evaluate their correlation with invasion and metastases.Methods Semiquantitative reverse transcription polymerase chain reaction analysis was performed to assess VEGF-A mRNA expression in 50 cases of endometrial carcinomas.Protein level was determined by Western blot.Results Increased levels of VEGF-A and VEGFR-1 mRNA and protein were found in endometrial carcinoma tissues comared with adjecent normal endometrial tissues.Expression of VEGF-A and VEGFR-1 gene were statistically analyzed to be related with depth of invasion.Significantly increased levels of VEGF-A in adenocarcinoma with poorly differentiated and undifferentiated carcinoma compared with well-and moderately differentiated adenocarcinoma.Conclusions Highly expressed VEGF-A and VEGFR-1 may induce invasion of endometrial carcinomas into myometrium.The more poorly differentiated the level of the carcinoma,the higher the level of the expression of VEGF-A." @default.
- W2376095264 created "2016-06-24" @default.
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- W2376095264 date "2008-01-01" @default.
- W2376095264 modified "2023-09-24" @default.
- W2376095264 title "Relationship between vascular endothelial growth factor A and its receptor 1 gene expression and biology character" @default.
- W2376095264 hasPublicationYear "2008" @default.
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