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- W2376115449 abstract "Objective To observe the pathological changes of articular cartilage of limbs foll owing is-chemia-reperfusion(IR)and to explore the injury mechanism o f articular cartilage.Methods In this investigation,35adult New Zealand white rabbits we re randomly divided into 7groups.Af ter 8hours of ischemia,the left hind limbs were reperfused(with the right side as the control).Then at 1day,3days,1weeks,2weeks,4weeks,8weeks and 12weeks,the grouped rabbi ts were killed respectively.The articular cartilages were excised from the knee joints.We observed the pathological changes of articular cartilage under light microscope and electron mic roscope.Results On the control side,the surface of articular cartilage was flat and chond rocytes were well-arranged and in good shape.On the left side,from 1w t o 2w after IR,large amounts of chondr ocytes degenerated and underwent necrosis,with disorder arrangemen t.At 4w and 8w,the articular facets were rough and chondrocytes broke off from the surface.At 12w,although neonate chondrocytes in articular cartila ge were discovered,the articular fa cets were rougher and even some ulcers appeare d on them and the collagen was exposed.Conclusion Following IR of limbs,degeneration and necrosis of chondr ocytes can occur in articular cartilage and the shape of cartilage will ch ange,which can result in the postoperative chro nic arthritis.[" @default.
- W2376115449 created "2016-06-24" @default.
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- W2376115449 date "2004-01-01" @default.
- W2376115449 modified "2023-09-24" @default.
- W2376115449 title "Pathological changes of articularc artilage of limbs following ischemi a-reperfusion" @default.
- W2376115449 hasPublicationYear "2004" @default.
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