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- W2376128412 abstract "Objective To study the relationship between endothelial nitric oxide synthase(eNOS)gene polymorphism and vascular cognitive impairment no dementia(V-CIND) after ischemic cerebral disease.Methods 180 patients with V-CIND after ischemic cerebral disease were divided into no cognitive impairment(NoCI) and V-CIND groups.They were all received cognitive assessment,such as MMSE, CDR and CSE-D,and then a total of 120 healthy people from the Health Management Center was recruited as control group(CR).Polymerase chain reaction combined with restrictive enzyme digestion was used to detect the G894T polymorphisms and 4a polymorphisms of eNOS gene in patients.Results There were significant differences in eNOSG894T genotype distribution and T allele frequency among V-CIND, NoCI and CR.Patients with V-CIND showed a significantly higher frequency of the T allele compared to the CR(19% vs 8.9%,χ2=10.301,P0.010,OR=1.73),patients with NoCI also showed a significantly higher frequency of the T allele compared to the CR(18.75% vs 8.9%,χ2=10.731,P0.010,OR=2.68),there was no difference in frequency of the T allele between V-CIND and NoCI.As to the frequency of the a allele,there were differences among three groups,but they had no statistical significance.Conclusions The G894T mutation of eNOS is related with V-CIND ischemic cerebral disease,T allele may be the susceptibility gene." @default.
- W2376128412 created "2016-06-24" @default.
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- W2376128412 date "2010-01-01" @default.
- W2376128412 modified "2023-09-25" @default.
- W2376128412 title "Association of endothelial nitric oxide synthase gene polymorphism with vascular cognitive impairment no dementia after ischemic cerebral disease" @default.
- W2376128412 hasPublicationYear "2010" @default.
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