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- W2376144328 abstract "Objective To investigate the expression of thyroid transcription factor 1(TTF-1) in different patterns of pulmonary adenocarcinoma and its relation to the origin of the tumour and to confirm the specificity of TTF-1 for pulmonary adenocarcinoma. Methods A tissue array including 133 cases of primary lung adenocarcinomas,9 primary salivary adenocarcinomas,and 14 pulmonary metastatic adenocarcinomas,as well as 5 pulmonary adenocarcinoma metastasized to other organs was studied.Immunohistochemical staining was performed on paraffin-embedded sections using anti-TTF-1 CDX2,ER,PR,PSA,CD10 and Tg antibodies. Results In normal lungs TTF-1 expressed in the terminal respiratory units.Furthermore, the expression was maintained in 85.7% of the adenocarcinoma.The staining in poorly differentiated adenocarcinomas was less than that in well-differentiated group(P=0.002).Of the peripheral adenocarcinomas exhibited higher positive expression than those of central bronchial origin(P=0.029). Conclusion TTF-1 staining is useful in the differential diagnosis of pulmonary adenocarcinomas and it may be a lineage marker for tumours arising from the peripheral airway or alveolar epithelium." @default.
- W2376144328 created "2016-06-24" @default.
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- W2376144328 date "2007-01-01" @default.
- W2376144328 modified "2023-09-25" @default.
- W2376144328 title "Significance of thyroid transcription factor-1(TTF-1) expression in pulmonary adenocarcinoma" @default.
- W2376144328 hasPublicationYear "2007" @default.
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