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- W2376149969 abstract "[Objective] To explore the acute toxicity of iron nano-particles to mice.[Methods] The mice were treated with a single oral dose of iron nano-particles and iron powder at 5 g/kg body weight.After14 days,the mice were sacrificed and the blood were collected,and then the serum was used for biochemical analysis.[Results] Less abnormal behaviors were observed at 5 g/kg oral dose of iron nano-particles and iron powder in mice. The live/body coefficient in iron nano-particles and iron powder groups was obviously higher than that in control group(P0.05).The serum unsaturated iron-binding capacity(UIBC)and total iron-binding capacity(TIBC) of iron nano-particles group were significantly lower than those of iron powder group(P0.05),but compared with control group without statistical significance. The levels of serum TOIL and Glu of iron nano-particles group were significantly lower than those in control group (P0.05).The levels of serum TBIL and Clu of iron powder have not any difference with control group.The serum LDH and TBA of bom iron nano-particles and iron powder groups were lower than those of control group. The serum BUN of iron nano-particles group was higher and serum Cr was lower compared with iron powder group. [Conclusion] In general, the iron nano-particles can be considered as less toxic and maybe has some special mechanisms of metabolism and toxicity compared with the iron powder of ordinary size." @default.
- W2376149969 created "2016-06-24" @default.
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- W2376149969 date "2004-01-01" @default.
- W2376149969 modified "2023-09-28" @default.
- W2376149969 title "Effect of Excess Iron Nano-particles on Serum Biochemical Indexes in Mice" @default.
- W2376149969 hasPublicationYear "2004" @default.
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