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- W2376163799 abstract "Objective To evaluate the efficacy and safety of lamivudine or entecavir treatment on patients with hepatitis B virus-associated glomerulonephritis(HBV-GN).Methods Totally 36 HBV-GN patients combined with chronic hepatitis B or liver cirrhosis were divided into 2 groups,with 25 patients in nucleos(t)ide analogue antiviral therapy group and 11 in control group.The antiviral therapy group received oral lamivudine 0.1 g or entecavir 0.5 mg once daily.The control group wasn't given antiviral therapy.Both the groups were given regular treatment for liver protection,enzyme reduction and the protection of renal function.Clinical markers including urinary protein,biochemical markers of liver and renal function and HBV serum markers and adverse reactions before and after treatment were observed.Results After 12 months of treatment,significant decrease in urinary protein and increase in serum albumin(ALB) were observed in antiviral therapy group,while no significant differences were found in urinary protein and serum ALB in the control group.ALT and AST levels decreased in both groups,but ALT and AST levels of the patients in antiviral therapy group decreased more significantly than those of the patients in the control group.Significant decrease in serum HBV DNA levels was observed in antiviral therapy group after treatment,while no significant difference in HBV DNA levels was found in the control group.Complete remission rate and total effective rate in the antiviral therapy group were higher than those in the control group.Conclusions Antiviral therapy with lamivudine or entecavir for HBV-GN achieves good efficacy in the significant decrease in urinary protein and HBV DNA levels,the increase in ALB levels and the relief of nephritic syndrome.Moreover,the patients have good tolerance of the antiviral therapy and no obvious adverse reactions are found." @default.
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- W2376163799 date "2010-01-01" @default.
- W2376163799 modified "2023-09-23" @default.
- W2376163799 title "Therapeutic efficacy of lamivudine or entecavir treatment on patients with hepatitis B virus-associated glomerulonephritis" @default.
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