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- W2376165770 abstract "The crystal structures of methyl 4-[N-(cyclopropyl-carbonyl)-N-phenylamino-]-1(2-phenylethyl)-4-piperidinecarboxylate (R32767) and N-[4-acetyl-1-(2-phenylethyl)-4-piperidinyl]-N-phenylpropanamide (R 32557) have been determined as part of a structure-activity relationship study on a series of 4-substituted fentanyl. R32767: C_(25)H_(30)N_2O_3; triclinic, pl; a=10.280(2),=b=10.367(1), c=12.170(1)A, α=92.28(1), β=102.31(1), γ=116.83(1)°, Z=2. R32557: C_(24)H_(30)N_2O_2·HCL·2H_20; triclinic, pl; a=9.369(6), b=9.680(6), c=14.799(9)A, α=86.24(5), β=76.23(5), γ=68.70(5)°, Z=2. The structures of the two are compared with those of R30490, R30730 and R4263. Preliminary study indicates that its toxicity is concerned with angles between the two aromatic rings and the piperidine ring. The potent analgesic activity may correspond to a torsion angle C_(14)-C_1-N_2-C_19 (according to locants of R32557) of about 120°." @default.
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- W2376165770 date "1987-11-01" @default.
- W2376165770 modified "2023-09-23" @default.
- W2376165770 title "[Studies on crystal structures and structure-activity relationships of the 4-substituted fentanyl derivatives]." @default.
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