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- W2376169878 abstract "Objective To investigate the relationship between chronic airway inflammation and pulmonary vascular remodeling and the effect of chronic airway inflammation on vascular endothelial growth factor(VEGF) and endothelin-1(ET-1) in rats.Methods Rat with chronic bronchitis(CB)and emphysema models were established to observe the pathomorphological changes of bronchi and pulmonary artery structure by image analysis.The levels of serum VEGF and plasma ET-1 were detected by ELISA and radioimmunoassay respectively.Results CB and emphysema were observed in model group.The thickness of the tunica media smooth muscles in the bronchial wall were significantly increased and the pathomorphological changes of pulmonary artery in model group were not significantly different from those in model group.The levels of serum VEGF and plasma ET-1 were not significantly higher in the model group than those in control group((P)(0.05).)Conclusions There is no direct effect of chronic airway inflammation on pulmonary vascular remodeling and the levels of VEGF and ET-1 in rats.Hypoxia,that is pathologic basis of chronic obstructive pulmonary disease(COPD),should be emerged if chronic airway inflammation were persisted for long term.So the prevention and cure on airway inflammation should be one of the key points on COPD prevention." @default.
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- W2376169878 date "2006-01-01" @default.
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- W2376169878 title "Empirical study on the change in pulmonary vascular structure and growth factor of rats with chronic airway inflammation" @default.
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