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- W2376173628 abstract "OBJECTIVE: To compare the clinical efficacy and safety of PEG4000 for functional constipation. METHODS: A total of 124 patients with chronic functional constipation entered a multi-center, randomized, comparative trial. Patients were divided into two groups treated with PEG4000(10g bid)as a treated group and psyllium hydrophilic mucilloid(6g bid) as a control for two weeks respectively. 64 patients were enrolled in PEG4000 group, all of them were assessable for safty and among of them 63 patients were assassable for efficacy, 60 patients were enrolled in psyllium hydrophilic mucilloid group, all of them were assessable for safty and among of them 59 patients were assessable for efficacy. RESULTS: The normalization of the stool form, frequncy of defecation and main digestive synptoms in the patients with chronic functional constipation was similar in the two groups. The total efficacy rates were 85.7% and 86.4% in the treatment group and controlled group respectively, there was no significant difference between the two groups; but in the rate of excellent efficacy there was significant difference they were 81 .0% and 62.7% in the treatment and controlled groups respectively (P 0.05%). The incidence of adverse reaction were 7.8% and 11 .7% in the two groups respectively, there was no difference (P0.05%). CONCLUSION: PEG4000 is a safe and effective agent in the treatment of chronic functional constipation." @default.
- W2376173628 created "2016-06-24" @default.
- W2376173628 creator A5069507022 @default.
- W2376173628 date "2001-01-01" @default.
- W2376173628 modified "2023-09-23" @default.
- W2376173628 title "A Randomized Controlled Multicenter Clinical Trial on the Treatment of Chronic Functional Constipation with PEG4000" @default.
- W2376173628 hasPublicationYear "2001" @default.
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