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- W2376176883 abstract "Objective To investigate the inhibition effect of Yin-chen-hao decoction( YCHT) on Kupffer cell activation and the prevention and treatment effect of YCHT on concanavalin A( ConA)-induced acute mice hepatitis.Methods Concanavalin A( ConA)-induced acute mice liver injury model were established by intravenous injection of ConA.After 8 hours,spleen body ratio,serum ALT activity and liver damage were determined.Moreover,serum TNF-α,IFN-γ level were determined with ELISA,TNF-α,CD68,CD163,F4 /80 mRNA expression of liver tissue were determined with Real-time QRT-PCR.Results Compared with model mice,spleen body ratio,serum ALT activity,TNF-α,IFN-γ level and liver damage,TNF-α,CD68,CD163,F4 /80 mRNA expression of liver tissue were markedly attenuated in YCHT group.Conclusion Yin-chen-hao decoction had a significant preventative effect on ConA-induced acute mice hepatitis by inhibiting the activation of Kupffer cells." @default.
- W2376176883 created "2016-06-24" @default.
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- W2376176883 date "2014-01-01" @default.
- W2376176883 modified "2023-09-24" @default.
- W2376176883 title "The Prevention and Treatment Effect of Yin-chen-hao Decoction on Concanavalin A-induced Acute Mice Hepatitis by Inhibiting the Activation of Kupffer cells" @default.
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