Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376184345> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2376184345 abstract "Objective To investigate the apoptotic effect and the changes of Bcl-2 protein expression of pEgr-hPTEN stable transfection in SHG-44 human glioma cells in combination with irradiation. Methods pEgr-hPTEN vector containing the exogenous wild type PTEN gene was transfected into SHG-44 cells under mediation of lipofectamine in vitro; the positive cell clones called SHG-44-hPTEN were selected and amplified by using G418. Transmission electron-microscope was used to detect the cell ultrastructural changes and flow cytometry to measure the apoptotic effect and Bcl-2 expression of SHG-44- hPTEN cells after X-ray irradiation at different doses. Results Many degenerative changes and early apoptotic changes including the chromosome condensate around the nuclear envelope were observed in SHG-44- hPTEN cells. pEgr-hPTEN stable transfection in combination with X-ray irradiation can significantly induce the apoptosis of SHG-44 cells. The percentage of early apoptosis is of SHG-44-hPTEN cells irradiated with X-rays at different doses was 1.5-2.3 times as much as that of SHG-44-hPTEN/0 Gy group, 1.9-4.4 times as much as that of SHG-44 irradiated group, and 3.4-5.1 times as much as that of SHG-44/0 Gy group. The expression of Bcl-2 proteins decreased in dose-dependent manner. Conclusion PTEN stable transfection in combination with irradiation can significantly induce the apoptosis of tumor cells and significantly down-regulate the expression of Bcl-2 protein.;" @default.
- W2376184345 created "2016-06-24" @default.
- W2376184345 creator A5057250525 @default.
- W2376184345 date "2006-01-01" @default.
- W2376184345 modified "2023-09-24" @default.
- W2376184345 title "Apoptosis and down-reguled expression of Bcl-2 in SHG-44 glioma cells induced by pEgr-hPTEN stable transfection in combination with X-ray irradiation" @default.
- W2376184345 hasPublicationYear "2006" @default.
- W2376184345 type Work @default.
- W2376184345 sameAs 2376184345 @default.
- W2376184345 citedByCount "0" @default.
- W2376184345 crossrefType "journal-article" @default.
- W2376184345 hasAuthorship W2376184345A5057250525 @default.
- W2376184345 hasConcept C104317684 @default.
- W2376184345 hasConcept C111337013 @default.
- W2376184345 hasConcept C121332964 @default.
- W2376184345 hasConcept C1491633281 @default.
- W2376184345 hasConcept C153911025 @default.
- W2376184345 hasConcept C185544564 @default.
- W2376184345 hasConcept C185592680 @default.
- W2376184345 hasConcept C190283241 @default.
- W2376184345 hasConcept C202751555 @default.
- W2376184345 hasConcept C2777609662 @default.
- W2376184345 hasConcept C40767141 @default.
- W2376184345 hasConcept C49923114 @default.
- W2376184345 hasConcept C54009773 @default.
- W2376184345 hasConcept C553184892 @default.
- W2376184345 hasConcept C55493867 @default.
- W2376184345 hasConcept C86554907 @default.
- W2376184345 hasConcept C86803240 @default.
- W2376184345 hasConcept C92087593 @default.
- W2376184345 hasConceptScore W2376184345C104317684 @default.
- W2376184345 hasConceptScore W2376184345C111337013 @default.
- W2376184345 hasConceptScore W2376184345C121332964 @default.
- W2376184345 hasConceptScore W2376184345C1491633281 @default.
- W2376184345 hasConceptScore W2376184345C153911025 @default.
- W2376184345 hasConceptScore W2376184345C185544564 @default.
- W2376184345 hasConceptScore W2376184345C185592680 @default.
- W2376184345 hasConceptScore W2376184345C190283241 @default.
- W2376184345 hasConceptScore W2376184345C202751555 @default.
- W2376184345 hasConceptScore W2376184345C2777609662 @default.
- W2376184345 hasConceptScore W2376184345C40767141 @default.
- W2376184345 hasConceptScore W2376184345C49923114 @default.
- W2376184345 hasConceptScore W2376184345C54009773 @default.
- W2376184345 hasConceptScore W2376184345C553184892 @default.
- W2376184345 hasConceptScore W2376184345C55493867 @default.
- W2376184345 hasConceptScore W2376184345C86554907 @default.
- W2376184345 hasConceptScore W2376184345C86803240 @default.
- W2376184345 hasConceptScore W2376184345C92087593 @default.
- W2376184345 hasLocation W23761843451 @default.
- W2376184345 hasOpenAccess W2376184345 @default.
- W2376184345 hasPrimaryLocation W23761843451 @default.
- W2376184345 hasRelatedWork W2403837832 @default.
- W2376184345 hasRelatedWork W2410122319 @default.
- W2376184345 hasRelatedWork W2443234167 @default.
- W2376184345 hasRelatedWork W2587324894 @default.
- W2376184345 hasRelatedWork W2589520965 @default.
- W2376184345 hasRelatedWork W2765786604 @default.
- W2376184345 hasRelatedWork W3028720195 @default.
- W2376184345 hasRelatedWork W3028770078 @default.
- W2376184345 hasRelatedWork W3029428454 @default.
- W2376184345 hasRelatedWork W3029463395 @default.
- W2376184345 hasRelatedWork W3030232161 @default.
- W2376184345 hasRelatedWork W3031547892 @default.
- W2376184345 hasRelatedWork W3031783979 @default.
- W2376184345 hasRelatedWork W3032599446 @default.
- W2376184345 hasRelatedWork W3140267005 @default.
- W2376184345 hasRelatedWork W3145921326 @default.
- W2376184345 hasRelatedWork W3146985867 @default.
- W2376184345 hasRelatedWork W3150152687 @default.
- W2376184345 hasRelatedWork W3152060191 @default.
- W2376184345 hasRelatedWork W3031479171 @default.
- W2376184345 isParatext "false" @default.
- W2376184345 isRetracted "false" @default.
- W2376184345 magId "2376184345" @default.
- W2376184345 workType "article" @default.