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- W2376200955 abstract "Objective To explore the distribution of VDR FokⅠ genotype in children who 1ived in areas with or without high fluoride,and to evaluate the relationship between children′s dental fluorosis and VDR FokⅠgene polymorphism.Methods Children aged 8 to 12 years,born and raised in high fluoride areas and contro1 areas in two counties of Henan province were recruited.They were divided into three groups according to dental fluorosis status:dental fluorosis group,non-dental fluorosis group from high fluoride area,and contorl group.The FokⅠmarker of VDR gene was genotyped using PCR-RFLP procedure.Fluoride levels in urine samples from the three groups were detected by fluoride ion selective electrode method.Results The prevalence rate of dental fluorosis in high fluoride areas was 51.7%.No dental fluorosis case was found in control areas.The frequency distribution of VDR FokⅠgenotype was FF 32.4%(24/74),Ff 45.9%(34/74),ff 21.6%(16/74)in children with dental fluorosis,FF 40.6%(28/69),Ff 36.2%(25/69),ff 23.2%(16/69)in children without dental fluorosis from high fluoride areas,and FF 31.9%(30/94),Ff 50.0%(47/94),ff 18.1%(17/94)in the children from contro1 areas,respectively.There was no significant difference among the three groups(P0.05).Conclusion There was no correlation between dental fluorosis and VDR FokⅠpolymorphism." @default.
- W2376200955 created "2016-06-24" @default.
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- W2376200955 date "2011-01-01" @default.
- W2376200955 modified "2023-09-23" @default.
- W2376200955 title "Relationship between vitamin D receptor FokIgene polymorphism and children′s dental fluorosis" @default.
- W2376200955 hasPublicationYear "2011" @default.
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