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- W2376202340 abstract "【Objective】To investigate expression of N-methyl-D-aspartate recaptors(NMDAR) and Calcitonin gene-related peptide(CGRP) in the spinal dorsal horn neurons induced by spared nerve injury of sciatic nerve.【Methods】twenty-seven healthy male Sprague-Dawley rats(220~280 g) were randomly devided into three groups(n=9): control group(group C),sham group(group sham),spared nerve injury model group(group SNI).These rats in group SNI which received a lesion of two of the three terminal branchesof the sciatic nerve(tibial and common peroneal nerves) leaving the remaining sural nerve intact.Mechanical allodynia and radiogenic heat pain thresholds of each group were measured on day 1 pre-surgery and on day 1,2,7,14 post-surgery.On day 2,7,14 post-surgery 2 hours after pain thresholds observation,the rats of each group were killed in batch(3 rats/batch),and the L5 spinal cord were dissected for determination of the expression of NMDAR and CGRP using immunohistochemical techniques.【Result】There were significant difference on the statistics in pain threshold in group SNI as comparede with that in group C and group sham(P0.01) on days 14 post-surgery,but the radiant heat stimulus paw withdrawal latency was no change in SNI group comparede with that in group C and group sham(P0.05).The expression of NMDAR and CGRP immunoreactive soma in the superficial laminae of the L5 spinal dorsal horn was significantly increased in group SNI than that in group C and group sham(P0.01).【Conclusion】Hyperpathia may be caused in the injured side limbs of rats following spared nerve injury of sciatic nerve.Simultaneously,neuronal NMDAR and CGRP expression may be significantly increased in rat spinal dorsal horn." @default.
- W2376202340 created "2016-06-24" @default.
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- W2376202340 date "2008-01-01" @default.
- W2376202340 modified "2023-09-23" @default.
- W2376202340 title "Changes of Nervronal N-methyl-D-aspartate Recaptors and Calcitonin Gene-related Peptide Expression in the Spinal Dorsal Horn Neuron Following Spared Nerve Injury of Sciatic Nerve in Rats" @default.
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