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- W2376207617 abstract "Objective To investigate the effects of MS-275,a sort of histone deacetylation inhibitor,acting on breast cancer cells MDA-MB-231 and MCF-7 by making ERα expression level increase or re-express and the effects of MS-275 on proliferation and apoptosis of breast cancer cells.Methods Treat breast cancer cells with MS-275 at different concentration(0.25 μmol/L,0.5 μmol/L,1.0 μmol/L,2.5 μmol/L),at the same time set the control group to compare.Draw the cells growing inhibiting curves by MTT test after the medicine intervention.Measure the ERα mRNA level by RT-PCR in breast cancer cells before or after the treatment(1.0μmol/L for 48 h).Then observe the biological behavior of breast cancer cells using Flow Cytometry method.Results MS-275 as a histone de-acetylation inhibitor could inhibit the growth of breast cancer cells significantly and its inhibiting effect contributed to the concentration and function time proved by MTT test.MDA-MB-231,ER-negative breast cancer cell,re-express ERα mRNA after treated with 1.0 μmol/L MS-275 for 48 h.MCF-7,ER-positive breast cancer cells,got an increased expression after the same treatment.And they all had significant differences.Tested by Flow Cytometry method,MS-275 can suspended the breast cancer cells generation at G1/S and G2/M period.This HDAC inhibitor also induce breast cancer cells apoptosis viewed by electron microscope.Conclusion MS-275 is a histone de-acetylation inhibitor.Its anti-tumor effect mostly depended on apoptosis.Meantime,it made a new therapy direction for it can cause ER-negative breast cancer cells re-express ERα." @default.
- W2376207617 created "2016-06-24" @default.
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- W2376207617 date "2011-01-01" @default.
- W2376207617 modified "2023-09-23" @default.
- W2376207617 title "The effect of HDAC inhibitor MS-275 on ERα expression of breast cancer cells" @default.
- W2376207617 hasPublicationYear "2011" @default.
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