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- W2376215649 abstract "Objective: To explore the influence of niflumic acid(NFA,10-1 000 μmol/L,a Cl-channel antagonist,on the membrane potentials and excitatory junction potential(EJP) in smooth muscle cells(SMCs) of cochlear spiral modiolar artery(SMA) in guinea pigs.Methods: NFA induced responses on the acutely isolated SMA preparation were recorded by the intracellular recording technique.Results: Bath application of NFA could cause hyperpolarizations in all the low resting potential(RP) cells,but had little effect on high RP cells.In low and high RP SMCs,NFA 100 μmol/L caused hyperpolarizations of(14.7±4.4) mV and(1.4±0.8) mV(P0.01),respectively.The NFA-induced responses were concentration-dependent in low RP SMCs.The hyperpolarization could be blocked by charybdotoxin and iberiotoxin.On the other hand,the majority of SMCs in vitro showed an EJP response to the transmural stimulation.NFA 100 μmol/L could not only notably inhibit the voltage but also shorten the time course of EJP in the high RP SMCs(P0.01) while had little effect on the low RP SMCs(P0.05).Conclusion: NFA not only induces concentration-dependent reversible hyperpolarizations via activation of the Ca2+-activated potassium channels,but also inhibits the EJP by blocking Ca2+-activated chloride conductance in SMCs of cochlear SMA.These findings suggest that NFA has a variety effect on SMCs." @default.
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- W2376215649 date "2010-01-01" @default.
- W2376215649 modified "2023-09-24" @default.
- W2376215649 title "Effect of Niflumic Acid on Membrane Potentials and Excitatory Junction Potential in Smooth Muscle Cells of Cochlear Spiral Modiolar Artery in Guinea Pigs" @default.
- W2376215649 hasPublicationYear "2010" @default.
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