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- W2376237117 abstract "Objective:To investigate the association of preoperative and postoperative plasma osteopontin (OPN)levels with tumor recurrence and prognosis in patients with hepatocellular carcinoma (HCC)after surgical resection. Methods:A total of 56 patients received liver resection for HCC were enrolled in this study. The association of the OPN levels with the clinicopathological characteristics,tumor recurrence,and disease-free survival (DFS)of HCC patients was analyzed. The associations of each marker or their combination with HCC recurrence and prognosis of HCC patients were studied. Results: The 1-year recurrent rates were 52.6% and 24.3%(P 0.05),DFS rates were 43.9% and 70.5%(P 0.05),respectively in higher and lower preoperative OPN level groups. The 1-year recurrent rates of higher and lower postoperative OPN level groups were 58.3% and 15.6%(P 0.01);DFS rates were 36.7% and 81.7%(P 0.01),respectively. Combined assessing preoperative and postoperative OPN levels,the 1 -year recurrent rates of the higher,middle and lower level groups were 70.0%,41.7% and 9.1%(P 0.01);DFS rates were 26.7% ,54.7% and 85.9%( P 0.01),respectively. The 1 -year predictive specificity of preoperative and postoperative OPN was 75.7% and 72.9% respectively. Combination of the two markers could achieve a specificity of 91.9% for 1 year,higher than that of single marker (P 0.05). Conclusion:The expression levels of plasma OPN were associated with postoperative recurrence and prognosis in patients with HCC. The combined evaluation of preoperative and postoperative plasma OPN levels may be helpful to predict the prognosis of HCC in patients after operation." @default.
- W2376237117 created "2016-06-24" @default.
- W2376237117 creator A5003053336 @default.
- W2376237117 date "2009-01-01" @default.
- W2376237117 modified "2023-09-23" @default.
- W2376237117 title "The Prognostic Value of Combined Assessment of Preoperative and Postoperative Plasma Levels of Osteopontin in Patients with Hepatocellular Carcinoma" @default.
- W2376237117 hasPublicationYear "2009" @default.
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