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• W2376239527 abstract "Objective To investigate the effects of ticagrelor on inhibiting platelet function of patients with coronary heart disease(CHD) and angina pectoris. Methods The patients(88 cases) diagnosed as angina pectoris in Fu Wai Hospital for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College from March 2011 to February 2012 were randomly divided into control group and treatment group according to the stratified randomization method, there were 44 cases in each group. On the basis of conventional therapy, the patients in the control group were orally given clopidogrel 300 mg/d loading dose, a week later changed to 75 mg/d to maintain for the treatment; The patients in the treatment group were orally given ticagrelor 180 mg/d loading does, a week later changed to 90 mg/d to maintain for the treatment. Before the treatment, 1 and 2 weeks after the administration, 6,12, and 24 h after stopping medication, the mean platelet aggregation(MPA) and mean platelet reactivity index(PRI) were observed. The number of patients with cardiovascular accidents and adverse drug reactions was detected during 1 year of the treatment. Results Before the treatment, the MPA and PRI in the two groups had no statistical difference(P 0.05). 1 and 2 weeks after the administration, the MPA and PRI in the treatment group were significantly lower than those in the control group(P 0.05). 12 and 24 h after stopping medication: The MPA and PRI in the treatment group were significantly higher than those in the control group(P 0.05). During 1 year of treatment, the cases of angina pectoris and myocardial infarction in the treatment group were significantly lower than those in the control group(P 0.05). The cases of contusion, abdominal pain and rash in the treatment group were significantly lower than those in the control group(P 0.05). The cases of dyspnea and bleeding in the two groups had no statistical difference. Conclusion Using ticagrelor instead of clopidogrel in the patients with angina pectoris may be effective against blood clotting platelets, and can recover faster after stopping medication, which can significantly reduce the incidences of angina pectoris and myocardial infarction, and the rate of death caused by cardiovascular and cerebrovascular accidents." @default.
• W2376239527 created "2016-06-24" @default.
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• W2376239527 date "2014-01-01" @default.
• W2376239527 modified "2023-09-26" @default.
• W2376239527 title "Inhibiting platelet function of ticagrelor on patients with coronary heart disease and angina pectoris" @default.
• W2376239527 hasPublicationYear "2014" @default.
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