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- W2376247655 abstract "Objective To investigate background knowledge of drug-resistant mutation among antiretroviral treatment-naive patients in Tianjin City,and compare the integrase gene polymorphism among different genetic subtype of HIV-1.Methods 50 blood samples of antiretroviral treatment-naive patients were collected randomly in 2010.Nested polymerase chain reaction(PCR) method was used to amplify integrase genes sequences of HIV-1 after DNA extracted.The nucleotide sequences of amplification products were determined,and the genetic subtype was identified by comparative analysis.Results Integrase gene fragments of HIV-1 were successfully amplified for 38 samples and 2 kinds of HIV-1 subtypes and recombinant gene were found.CRF01_AE was major subtype,accounted for 73.68%(28/38) of all positives.B was the second,accounted for 26.32%(10/38).Only one individual was drug resistant,and the rate of drug resistance was 2.63%(1/38).It was low-level resistance for elvitegravir.The genotype was R263KR.The integrase gene polymorphism was different in different gene subtypes.Conclusions The polymorphism and drug-resistant mutation of HIV-1 integrase gene were different in different gene subtypes in Tianjin.We should continue to study the integrase gene sequence features,to be master of baseline data,so as to provide a scientific basis for carrying out anti-viral treatment better." @default.
- W2376247655 created "2016-06-24" @default.
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- W2376247655 date "2013-01-01" @default.
- W2376247655 modified "2023-09-26" @default.
- W2376247655 title "Study on integrase gene polymorphism and drug resistance among antiretroviral treatment-naive patients in Tianjin City" @default.
- W2376247655 hasPublicationYear "2013" @default.
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