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- W2376256811 abstract "Objective To investigate the risk factors for cardiorespiratory failure in infants with hand,foot and mouth disease,and to develop a reliable prediction system for the early diagnosis and management of the severe patients.Methods One hundred and ninety-nine hospitalized infants with hand,foot and mouth disease were enrolled.The patients were divided into two groups based on presence and absence of cardiorespiratory failure.Based on available documents,17 clinical measures were studied as the possible risk factors,including gender,age,the highest temperature,heart rate,respiratory rate,blood pressure,EV71 infection,rashes,drowsiness,vomiting,abnormal respiratory rhythm,limb asthenia,convulsion,the time from eruption of skin rash or oral ulcer to the appearance of central nervous system symptoms,peripheral blood leukocytes,percentage of lymphocyte,and random glucose level.Logistic regression was used to examine the relationship between risk factors and cardiorespiratory failure.A risk score model was built according to the above factors.The predictive effect of the model was evaluated by sensitivity,specificity,consistency and area under receiver operating characteristic(ROC)curve.Results In the multivariable analysis,4 variables in the risk evaluation model(the highest temperature,vomiting,random glucose level and abnormal respiratory rhythm)remained independent predictors of the outcome.The risk score model highly predicted cardiorespiratory failure.The area under the ROC curve for the evaluation model was 0.994.when the prediction was performed based on the existing date using the presut model,the sensitivity,specificity and consistency of the model were 94.12%(64/68),97.71%(128/132)and 94.48%(192/199),respectively.Conclusions The risk score model was a quantitative and effective tool for predicting cardiorespiratory failure in infants with hand,foot and mouths disease." @default.
- W2376256811 created "2016-06-24" @default.
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- W2376256811 date "2012-01-01" @default.
- W2376256811 modified "2023-09-23" @default.
- W2376256811 title "Risk factors for cardiorespiratory failure in infants with hand,foot and mouth disease and establishment of risk score model" @default.
- W2376256811 hasPublicationYear "2012" @default.
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