Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376259993> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2376259993 abstract "Objective To test the anti-tumor effect of AL3810 on A549 human lung adenocarcinoma.Methods ①The antiproliferative effects of AL3810 against 13 human carcinoma cell lines and MRC-5 cell line in vitro were observed by MTT assay.②The effects of AL3810 on cell cycle distribution and induction of apoptosis were assessed by flow cytometry analysis.③The effects of AL3810 on the active caspase-3 of A549 cell line were assessed by flow cytometry analysis.④The effect of AL3810 on cell migration was determined by wound assay.⑤The dose-effect relationship on antitumor effect of AL3810 was evaluated in vivo with the model of nude mice bearing A549 xenografts.Results AL3810 inhibited most of the cell lines significantly.AL3810 had the ability to induce apoptosis of A549 cell,and also showed in time dependent manner.In addition,AL3810 was also observed to block cells in G0-G1phase of cell cycle.AL3810 activated the caspase-3 in cells with a time dependent manner.Cell migration was also inhibited by AL3810 and the effects were time dependent.AL3810 showed significant inhibitive effects and the dose-effect relationship of tumor growth in xenografted nude mice.Conclusion AL3810 inhibited the proliferation of several tumor cell lines while differed in inhibition degree.The mechanisms of AL3810 might be associated with induction of tumor cells apoptosis,G0-G1 phase arrest,activation of caspase-3 and inhibiting the migration of A549 cell." @default.
- W2376259993 created "2016-06-24" @default.
- W2376259993 creator A5077343778 @default.
- W2376259993 date "2013-01-01" @default.
- W2376259993 modified "2023-09-26" @default.
- W2376259993 title "Anti-tumor effects of AL3810 on A549 human lung adenocarcinoma" @default.
- W2376259993 hasPublicationYear "2013" @default.
- W2376259993 type Work @default.
- W2376259993 sameAs 2376259993 @default.
- W2376259993 citedByCount "0" @default.
- W2376259993 crossrefType "journal-article" @default.
- W2376259993 hasAuthorship W2376259993A5077343778 @default.
- W2376259993 hasConcept C121608353 @default.
- W2376259993 hasConcept C126322002 @default.
- W2376259993 hasConcept C1491633281 @default.
- W2376259993 hasConcept C150903083 @default.
- W2376259993 hasConcept C190283241 @default.
- W2376259993 hasConcept C203014093 @default.
- W2376259993 hasConcept C207001950 @default.
- W2376259993 hasConcept C2780278673 @default.
- W2376259993 hasConcept C2780783641 @default.
- W2376259993 hasConcept C2781182431 @default.
- W2376259993 hasConcept C29537977 @default.
- W2376259993 hasConcept C502942594 @default.
- W2376259993 hasConcept C54355233 @default.
- W2376259993 hasConcept C553184892 @default.
- W2376259993 hasConcept C55493867 @default.
- W2376259993 hasConcept C62112901 @default.
- W2376259993 hasConcept C71924100 @default.
- W2376259993 hasConcept C81729549 @default.
- W2376259993 hasConcept C81885089 @default.
- W2376259993 hasConcept C86803240 @default.
- W2376259993 hasConceptScore W2376259993C121608353 @default.
- W2376259993 hasConceptScore W2376259993C126322002 @default.
- W2376259993 hasConceptScore W2376259993C1491633281 @default.
- W2376259993 hasConceptScore W2376259993C150903083 @default.
- W2376259993 hasConceptScore W2376259993C190283241 @default.
- W2376259993 hasConceptScore W2376259993C203014093 @default.
- W2376259993 hasConceptScore W2376259993C207001950 @default.
- W2376259993 hasConceptScore W2376259993C2780278673 @default.
- W2376259993 hasConceptScore W2376259993C2780783641 @default.
- W2376259993 hasConceptScore W2376259993C2781182431 @default.
- W2376259993 hasConceptScore W2376259993C29537977 @default.
- W2376259993 hasConceptScore W2376259993C502942594 @default.
- W2376259993 hasConceptScore W2376259993C54355233 @default.
- W2376259993 hasConceptScore W2376259993C553184892 @default.
- W2376259993 hasConceptScore W2376259993C55493867 @default.
- W2376259993 hasConceptScore W2376259993C62112901 @default.
- W2376259993 hasConceptScore W2376259993C71924100 @default.
- W2376259993 hasConceptScore W2376259993C81729549 @default.
- W2376259993 hasConceptScore W2376259993C81885089 @default.
- W2376259993 hasConceptScore W2376259993C86803240 @default.
- W2376259993 hasLocation W23762599931 @default.
- W2376259993 hasOpenAccess W2376259993 @default.
- W2376259993 hasPrimaryLocation W23762599931 @default.
- W2376259993 hasRelatedWork W2163991744 @default.
- W2376259993 hasRelatedWork W218838815 @default.
- W2376259993 hasRelatedWork W2200919180 @default.
- W2376259993 hasRelatedWork W2347272947 @default.
- W2376259993 hasRelatedWork W2351789248 @default.
- W2376259993 hasRelatedWork W2351812606 @default.
- W2376259993 hasRelatedWork W2356764976 @default.
- W2376259993 hasRelatedWork W2357081353 @default.
- W2376259993 hasRelatedWork W2357580061 @default.
- W2376259993 hasRelatedWork W2358073269 @default.
- W2376259993 hasRelatedWork W2359459995 @default.
- W2376259993 hasRelatedWork W2375619116 @default.
- W2376259993 hasRelatedWork W2382259096 @default.
- W2376259993 hasRelatedWork W2384284429 @default.
- W2376259993 hasRelatedWork W2386670487 @default.
- W2376259993 hasRelatedWork W2391256472 @default.
- W2376259993 hasRelatedWork W2392080789 @default.
- W2376259993 hasRelatedWork W2404195220 @default.
- W2376259993 hasRelatedWork W2419125918 @default.
- W2376259993 hasRelatedWork W2789767397 @default.
- W2376259993 isParatext "false" @default.
- W2376259993 isRetracted "false" @default.
- W2376259993 magId "2376259993" @default.
- W2376259993 workType "article" @default.