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- W2376260963 abstract "Objective: To investigate the dynamic changes of malonyldialdehyde, endothelin-1 (ET-1) and vascular en-dothelial growth factor (VEGF)in atherosclerosis progression. Methods: Forty rabbits were randomly divided into 2 groups:control group and atherosclerosis group. At the end of 4th,8th and 12th weeks,blood samples were obtained for serum malonyldialdehyde assay. Meanwhile, 5 - 8 cases of aorta were harvested and the pathological changes were observed. ET-1 and VEGF were studied with immunohistochemical techniques at the different stages of atherosclerosis progression. Results: (l)The lesions in atherosclerosis group were aggravated during the progression of atherosclerosis. (2) Compared with the control group,malonyldialdehyde in serum of atherosclerosis group was remarkably increased. Furthermore, the level of malonyldialdehyde was gradually elevated in atherosclerosis group as time goes by. (3)The intensity and scope of ET-1, VEGF immunoreactivity were increased with the pathology development. Conclusion: Lipid peroxide (LPO) ,ET-1, VEGF works together and play roles in atherosclerosis development." @default.
- W2376260963 created "2016-06-24" @default.
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- W2376260963 date "2003-01-01" @default.
- W2376260963 modified "2023-09-23" @default.
- W2376260963 title "Dynamic changes of malonyldialdehyde,ET-1, VEGF in atherosclerosis progression" @default.
- W2376260963 hasPublicationYear "2003" @default.
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