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- W2376265587 abstract "Objective To observe the changes of AQP4 expression and TNF-α in the neonatal rats with hypoxic-ischemic encephalopathy(HIE). Methods Seven-day-old neonatal rats were devided into seven groups, including control group(n=5) and operation group(n=30), The operation group was executed after HIE at 0,2,4,6,8 and 12 h,respectively. Its brain issue was collected to quantify the changes in the area of the AQP4-positive cell by immunocytochemistry analysis. TNF-α levels were detected by radioimmunological methods. Results The AQP4 expression was predominantly observed in choroids plexus, ependyma, hippocampus and edema area. With the progress of the time, the expression of AQP4 increased slowly. The pathologic changes of the stage were intracellular inflammatory reaction. Contents of TNF-α were significantly increased 2 h in operation group than control group(P 0.05).Conclusions AQP4 and TNF-α are closely related with the development of brain edema after HIE. So, inhibition of AQP4 and TNF-α will be a new way to treat HIE." @default.
- W2376265587 created "2016-06-24" @default.
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- W2376265587 date "2007-01-01" @default.
- W2376265587 modified "2023-09-26" @default.
- W2376265587 title "Changes of aquaporion-4(AQP4)and TNF-α in the neonatal rats with hypoxic-ischemic encephalopathy" @default.
- W2376265587 hasPublicationYear "2007" @default.
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