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- W2376272135 abstract "Objective: To explore the effects of glycoproteins from Astragalus membranaceus( HQGP) on proliferation and apoptosis of splenocytes in adjuvant arthritis( AA) rats. Methods: AA models were established for one week and splenocytes were prepared and treated with drugs in concentration gradients. Effects of HQGP on proliferation of splenocytes were detected with MTT experiments. Rats were divided into six groups and immuned. Drugs were applied in concentration gradients after one week. Spleens were collected after three weeks and prepared to ultrathin sections. HE stain was performed to observe the histomorphology of spleens. In situ cell apoptosis of spleens was investigated through TUNEL assay. Expression levels of apoptotic proteins Bax and Bcl- 2 and intranuclear transcription factor Foxp3 were detected by immunohistochemistry tests. Results: The results of MTT experiments showed that HQGP inhibited proliferation of splenocytes( P 0. 01). The TUNEL assay demonstrated percentage of apoptotic splenocytes was raised( P 0. 01) by HQGP. Immunohistochemistry displayed that HQGP regulated the expression of Bax and Bcl- 2 and enhanced the expression of Foxp3 in AA rats. Conclusion: This study demonstrates that HQGP may suppress cellular immunity through inhibiting proliferation of T cells. Induction of splenocytes apoptosis may be due to adjusting of Bax and Bcl- 2 expression. Immunologic tolerance may be improved by up- regulated Foxp3 expression." @default.
- W2376272135 created "2016-06-24" @default.
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- W2376272135 date "2014-01-01" @default.
- W2376272135 modified "2023-09-23" @default.
- W2376272135 title "Effects of Glycoproteins from Astragalus Membranaceus on Proliferation and Apoptosis of Splenocytes in Adjuvant Arthritis Rats" @default.
- W2376272135 hasPublicationYear "2014" @default.
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