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- W2376290876 abstract "Objective To investigate the features of 18F-FDG PET/CT for multiple myeloma(MM) and to explore the value of 18F-FDG PET/CT in the diagnosis of MM. Methods 18F-FDG PET/CT imaging findings were retrospectively analyzed in 19 patients with MM proved by bone marrow aspiration biopsy.SUVmean of those lesions were measured. Results All patients suffered from multiple lesions in bone.A total of 221 lesions(about 85.3% of all lesions) were found by CT,which showed as punched out or bubbly lytic destructions of bone.All lesions were mostly found in bone marrow of axial skeleton,and rarely formed soft tissue masses and extramedullary organ involvement.A total of 198 lesions(about 76.4%) in bone got focal 18F-FDG uptake increasing in PET and SUVmean was 3.1±1.4(1.3-7.4).PET of the lesions with hypermetabolism were generally matched with CT results,but not matched completely in some lesions.Characteristics of PET/CT images were categorized into three types: ①Multiple bone destructions were shown by CT in partial patients,which mismatched with the hypermetabolism lesions by PET.②Some lesions were found with hypermetabolism by PET,but no bone destructions in CT.③The bone destructions combined with soft tissue mass with hypermetabolism in PET were similar to CT results.Two patients with negative results by routine bone marrow aspiration were proved as MM by bone marrow biopsy guided by PET/CT. Conclusion 18F-FDG PET/CT imaging has an important value in diagnosing MM.Bone marrow aspiration biopsy guided by 18F-FDG PET/CT can improve the diagnostic sensitivity,especially in those false-negative patients." @default.
- W2376290876 created "2016-06-24" @default.
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- W2376290876 date "2012-01-01" @default.
- W2376290876 modified "2023-09-23" @default.
- W2376290876 title "Clinical application of ~(18)F-FDG PET/CT in diagnosis of multiple myeloma" @default.
- W2376290876 hasPublicationYear "2012" @default.
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