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- W2376291251 abstract "Objective: To study the anti-tumor efficacy induced by antibodized tumor epitope PDTRP gene immunization. Methods: Three copies of tumor associate gene PDTRP from MUCI tandem repeats were designed and mimicked the conformation of MUCI by Insight Ⅱ . The γlneo-PDTRP plasmid was further constructed, in which the PDTRP target gene was inserted into CDR3 of the γ1 -neo vector. The specific humoral and cellular immune responses towards to PDTRP were detected after intraspleen immunized Balb/c mice with ylneo-PDTRP. And the immune protection assay was also done to observe whether the mice immunized with γlneo-PDTRP could prolong the survival after tumor challenge. Results: The conformation of three copies of PDTRP mimicked the conformation of MUCI tandem repeats. The expression of γlneo-PDTRP could be detected after in vitro transfect. The specific antibody against PDTRP epitope could be induced and increase to a higher titer after intraspleen injection with a γlneo-PDTRP plasmid. And the specific proliferation and cytotox-ic function of lymphocyte were also increased. There is a significant survival from mice immunized with γlneo-PDTRP a-gainst the 4T1-PDTRP tumor challenge. Conclusions: Gene immunization with γlneo-PDTRP could elicit both humoral and cellular tumor specific immune response and had the protective effect." @default.
- W2376291251 created "2016-06-24" @default.
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- W2376291251 date "2004-01-01" @default.
- W2376291251 modified "2023-09-22" @default.
- W2376291251 title "Anti-Tumor Efficacy Induced by Antibodized PDTRP Gene Immunization" @default.
- W2376291251 hasPublicationYear "2004" @default.
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