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- W2376292078 abstract "Objective To approach the alteration of insulin resistance in pregnant women with polycystic ovary syndrome(PCOS) and the relationship with pregnancy outcomes.Methods Between Sep.2007 and Feb.2009,One hundred and two pregnant women with PCOS diagnosed in the second affiliated hospital,Sun Yat-sen University were PCOS group,at the same time 701 normal pregnant women were selected as control group.The complication and pregnancy outcome were compared between the two groups.At equal pace,38 pregnant women in PCOS group and 50 pregnant women in control group underwent a 75g oral glucose tolerance test and insulin-releasing test within 24th~28th pregnancy weeks.HOMA-IR,HOMA-β and AUCglu and AUCins were calculated.Results The AUCglu and AUCins of PCOS group were significantly higher than control group(22.22 ±4.48 vs 19.29±3.19 and 228.93±130.05 vs 155.62±69.54,P0.05),the mean serum fasting insulin and glucose levels,thus HOMA-IR,HOMA-β of women with PCOS were higher than those of the control subjects(4.61±0.57 vs 4.56±0.39,7.81±4.65 vs 6.35±4.45,1.65±1.08 vs 1.31±0.95,169.47±119.4 vs 126.94±85.81 respectively) but there was no significant difference.Compared with control group,patients with PCOS bore significantly higher rates of miscarriage(23.53 vs 8.27%),gestational diabetes mellitus(31.37% vs 6.56%),preterm delivery(11.76% vs 5.85%) and macrosomia(5.88% vs 1.14%),P0.05.Conclusion The insulin resistance,spontaneous abortion,gestational diabetes mellitus,preterm delivery and macrosomia in women with PCOS were significantly higher than that in control group." @default.
- W2376292078 created "2016-06-24" @default.
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- W2376292078 date "2011-01-01" @default.
- W2376292078 modified "2023-09-28" @default.
- W2376292078 title "Insulin resistance and pregnancy outcome in women with polycystic ovary syndrome" @default.
- W2376292078 hasPublicationYear "2011" @default.
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