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- W2376294672 abstract "Objective:To investigate the renal expression of the transforming growth factor-β1 (TGF-β1) and fibronectin(FN) in murine chronic graft-versus-host disease(cGVHD) lupus nephritis and to investigate the interventional effect of mycophenolate mofetilv(MMF) on it. Methods:Mice models of cGVHD lupus nephritis were established. Mice were randomly divided into three groups, namely control group, model group, MMF treated group. Histopathology, renal function and proteinuria were observed. The expressions of TGF-β1 and FN mRNA were assessed by Real-time PCR and the protein levels of TGF-β1 and FN were detected by Western blotting. Results:Real-time PCR and Western blotting results showed that the expressions of TGF-β1 and FN were significantly increased in renal tissue of cGVHD mice, and the level of BUN and Ccr in serum and proteinuria were also higher than those in control group. MMF ameliorated the histological lesions, maintained normal renal function, normalized proteinuria and suppressed TGF-β1 and FN expression. Conclusion:This study suggests that the TGF-β1 may be involved in the pathogenesis of lupus nephritis. The beneficial effect of MMF on lupus nephritis may be partially mediated by the inhibition of TGF-β1." @default.
- W2376294672 created "2016-06-24" @default.
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- W2376294672 date "2011-01-01" @default.
- W2376294672 modified "2023-09-23" @default.
- W2376294672 title "Inhibition of Mycophenolate Mofetil on Over-expression of TGF-β_1 and FN in Renal Tissue of Murine Chronic Graft-versus-host Disease Lupus Nephritis" @default.
- W2376294672 hasPublicationYear "2011" @default.
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