Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376297672> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2376297672 endingPage "9" @default.
- W2376297672 startingPage "485" @default.
- W2376297672 abstract "Recent researches indicate that ubiquitin-protea some pathway plays an important role in apoptosis regulation. Proteasome inhibitors induce apoptosis in many kinds of neoplastic cells, thus provide a great opportunity for exploring synergy of proteasome inhibitors and other apoptosis-inducing agents. In this study, the effect of the proteasome inhibitor Z-LLL-CHO combined with etoposide (VP16) on leukemic cell lines M-07e and TF-1 was investigated by MTT assay, trypan blue exclusion, flow cytometry and Western blot. The results showed that the combination of Z-LLL-CHO and VP16 was much more effective than either agents alone in promoting cytotoxicity in both cell lines evaluated. Accumulation of cells in S + G2/M phase of the cell cycle was observed in the cells treated with VP16 and Z-LLL-CHO alone, while apparent increase of sub-G0/G1 fraction was detected in cells treated with combination of the agents. The cleavage of Bcl-2 into a shortened 22 kD fragment was detected in M-07e cells exposed to either agents alone, and the fraction of 22 kD fragment was increased in the cells treated with combination of the agents. In conclusion, the combination of Z-LLL-CHO and VP16 enhanced their individual cytotoxic effect by inducing apoptosis, in which increase of S + G2/M fraction in cell cycle as well as the enhanced cleavage of Bcl-2 are the possible mechanism of the additive effect on leukemic cells by Z-LLL-CHO and VP16." @default.
- W2376297672 created "2016-06-24" @default.
- W2376297672 creator A5017676873 @default.
- W2376297672 creator A5030842813 @default.
- W2376297672 creator A5060514130 @default.
- W2376297672 creator A5083456129 @default.
- W2376297672 date "2003-10-01" @default.
- W2376297672 modified "2023-09-30" @default.
- W2376297672 title "[Enhanced apoptosis-inducing effect of etoposide on leukemic cell lines M-07e and TF-1 by the proteasome inhibitor Z-LLL-CHO]." @default.
- W2376297672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14575542" @default.
- W2376297672 hasPublicationYear "2003" @default.
- W2376297672 type Work @default.
- W2376297672 sameAs 2376297672 @default.
- W2376297672 citedByCount "1" @default.
- W2376297672 crossrefType "journal-article" @default.
- W2376297672 hasAuthorship W2376297672A5017676873 @default.
- W2376297672 hasAuthorship W2376297672A5030842813 @default.
- W2376297672 hasAuthorship W2376297672A5060514130 @default.
- W2376297672 hasAuthorship W2376297672A5083456129 @default.
- W2376297672 hasConcept C109316439 @default.
- W2376297672 hasConcept C153911025 @default.
- W2376297672 hasConcept C154317977 @default.
- W2376297672 hasConcept C185592680 @default.
- W2376297672 hasConcept C190283241 @default.
- W2376297672 hasConcept C202751555 @default.
- W2376297672 hasConcept C27740335 @default.
- W2376297672 hasConcept C2776694085 @default.
- W2376297672 hasConcept C2778119113 @default.
- W2376297672 hasConcept C2778367456 @default.
- W2376297672 hasConcept C2780783641 @default.
- W2376297672 hasConcept C29537977 @default.
- W2376297672 hasConcept C502942594 @default.
- W2376297672 hasConcept C54355233 @default.
- W2376297672 hasConcept C55493867 @default.
- W2376297672 hasConcept C81885089 @default.
- W2376297672 hasConcept C86803240 @default.
- W2376297672 hasConcept C95444343 @default.
- W2376297672 hasConceptScore W2376297672C109316439 @default.
- W2376297672 hasConceptScore W2376297672C153911025 @default.
- W2376297672 hasConceptScore W2376297672C154317977 @default.
- W2376297672 hasConceptScore W2376297672C185592680 @default.
- W2376297672 hasConceptScore W2376297672C190283241 @default.
- W2376297672 hasConceptScore W2376297672C202751555 @default.
- W2376297672 hasConceptScore W2376297672C27740335 @default.
- W2376297672 hasConceptScore W2376297672C2776694085 @default.
- W2376297672 hasConceptScore W2376297672C2778119113 @default.
- W2376297672 hasConceptScore W2376297672C2778367456 @default.
- W2376297672 hasConceptScore W2376297672C2780783641 @default.
- W2376297672 hasConceptScore W2376297672C29537977 @default.
- W2376297672 hasConceptScore W2376297672C502942594 @default.
- W2376297672 hasConceptScore W2376297672C54355233 @default.
- W2376297672 hasConceptScore W2376297672C55493867 @default.
- W2376297672 hasConceptScore W2376297672C81885089 @default.
- W2376297672 hasConceptScore W2376297672C86803240 @default.
- W2376297672 hasConceptScore W2376297672C95444343 @default.
- W2376297672 hasIssue "5" @default.
- W2376297672 hasLocation W23762976721 @default.
- W2376297672 hasOpenAccess W2376297672 @default.
- W2376297672 hasPrimaryLocation W23762976721 @default.
- W2376297672 hasRelatedWork W1977306665 @default.
- W2376297672 hasRelatedWork W1981071449 @default.
- W2376297672 hasRelatedWork W2041847326 @default.
- W2376297672 hasRelatedWork W2044731171 @default.
- W2376297672 hasRelatedWork W2050173373 @default.
- W2376297672 hasRelatedWork W2054186356 @default.
- W2376297672 hasRelatedWork W2078800147 @default.
- W2376297672 hasRelatedWork W2092238768 @default.
- W2376297672 hasRelatedWork W2094589798 @default.
- W2376297672 hasRelatedWork W2104130860 @default.
- W2376297672 hasRelatedWork W2104884931 @default.
- W2376297672 hasRelatedWork W2159415442 @default.
- W2376297672 hasRelatedWork W2170364983 @default.
- W2376297672 hasRelatedWork W2276599236 @default.
- W2376297672 hasRelatedWork W2335526988 @default.
- W2376297672 hasRelatedWork W2369276931 @default.
- W2376297672 hasRelatedWork W2396782562 @default.
- W2376297672 hasRelatedWork W2412597024 @default.
- W2376297672 hasRelatedWork W2502469938 @default.
- W2376297672 hasRelatedWork W2521385183 @default.
- W2376297672 hasVolume "11" @default.
- W2376297672 isParatext "false" @default.
- W2376297672 isRetracted "false" @default.
- W2376297672 magId "2376297672" @default.
- W2376297672 workType "article" @default.