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- W2376299737 abstract "Objective To study the clinicopathologic features,immunophenotype and differential diagnosis of clear-cell variant of papillary thyroid carcinoma(CPTC).Methods The clinical and histopathologic features were analyzed in a case of CPTC.Immunohistochemical and AB-PAS stains were carried out on paraffin-embedded tissues,and relevant literatures were reviewed.Results A nodule from thyroid isthmic portion of a 60-year-old woman was analyzed.Grossly,the ovoid mass measured 4.8×4×3.5 cm was encapsulated,firm,focally gelatinous,yellow and partially hemorrhagic.Microscopically,it was composed of solid areas and follicles filled with colloid or mucus.No papillay structure was seen.Ground-glass nuclei,nuclear groovings and pseudoinclusions were present.Some solid areas showed remarkably clear cells.Immunohistochemisty showed that all the tumor cells including clear cells were positive for TTF-1,Tg,galectin-3 and CK19,and negative for HBME-1,calcitonin,CD10,RCC and vimentin.Periodic acid Schiff(PAS)-positive granules were seen in the cytoplasm of the tumor cells and Alcian blue(AB)-positive mucus was seen in the follicles.The colloid in the follicles was also PAS-positive.Conclusion CPTC is a rare variant of papillary thyroid carcinoma.It is difficult to make differential diagnosis from renal cell carcinoma metastatic to thyroid microscopically,and immunohistochemical and PAS staining may be of great help." @default.
- W2376299737 created "2016-06-24" @default.
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- W2376299737 date "2013-01-01" @default.
- W2376299737 modified "2023-09-24" @default.
- W2376299737 title "Clear-cell variant of papillary thyroid carcinoma:a clinicopathological study" @default.
- W2376299737 hasPublicationYear "2013" @default.
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