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- W2376306847 abstract "Objective: To explore the effect of Shenfutang (SFT) in up regulating expressions of heat shock protein (HSP) mRNA and glucocorticoid receptor (GR)mRNA and its influence on cell survival. Methods: HSP cell model was established. SFT containing serum was prepared with animal serologic method. Changes of HSPmRNA and GRmRNA were analyzed by Northern blot and cell survival rate was determined by Trypan blue staining test. Results: During HSP reaction, GRmRNA decreased obviously, cell survival rate lowered and HSPmRNA increased in HL60 cell line, while in the cell line being treated with SFT, during HSP reaction, GRmRNA and cell survival rate increased and HSPmRNA increased further. Conclusion: SFT could up regulate the expressions of HSPmRNA and GRmRNA in HL60 cell line, raise the biological activity and injure antagonizing capacity of glucocorticoid, thus to increase the survival rate of HL60 cell line during heat shock reaction. These may be the mechanism of SFT therapy used in clinical practice." @default.
- W2376306847 created "2016-06-24" @default.
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- W2376306847 date "2003-01-01" @default.
- W2376306847 modified "2023-09-23" @default.
- W2376306847 title "Effect of Shenfutang in Up-regulating Expressions of Heat Shock Protein mRNA and Glucocorticoid Receptor mRNA and Its Influence on Cell Survival" @default.
- W2376306847 hasPublicationYear "2003" @default.
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