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- W2376340543 abstract "Objective To determine the effect of active part extracted from Tadehagi trquetrum(Lim.) Ohashi on type Ⅰ allergy induced by IgE.Methods Tadehagi trquetrum(Linn.) Ohashi was extracted by 50% acetone.The 50% acetone extractions were again extracted by EtOAc and isolated by D101 chromatography column.We got 50% acetone extraction(1),EtOAc extraction(2),H2O layer(3),residue(4),and enriched extract by macroporous resin D101(5).Rats were sensitized with the mixture of OVA and Al(OH)3 to establish the experimental rat model of type Ⅰ allergy.The rats were divided into 13 groups ramdomly,namely a normal group,a model group,a menglusitena group,and sample group 1,2,3,4,5 at 100 mg·kg-1 or 400 mg·kg-1 respectively.IgE,LT and His contents in the serum of sensitized rats were measured with ELISA.The inflammatory area in the pulmonary tissues through pathological examination.Results Group 1,2,3 decreased the contents of IgE,LT and His in the serum.The active sequence was 123.Group 1 reduced the quantities of EOS in whole blood and BALF;Group 1 and 2 reduced the inflammatory areas in the pulmonary tissue,and the active sequence was 12.Conclusion Group 1,2,and 3 have obvious anti-alergy effect on type Ⅰ allergy and the active sequence is 123." @default.
- W2376340543 created "2016-06-24" @default.
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- W2376340543 date "2011-01-01" @default.
- W2376340543 modified "2023-09-26" @default.
- W2376340543 title "Effect of active part extracted from Tadehagi trquetrum(Linn.) Ohashi on type I allergy induced by IgE" @default.
- W2376340543 hasPublicationYear "2011" @default.
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