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- W2376350154 abstract "Objective To investigate the expression of matrix metalloproteinases2 (MMP2)and tissue inhibitors of metalloproteinases2 (TIMP2) in renal clear cell carcinoma (RCCC),and to explore their correlation with pathologic grade and stage of the tumors. Methods The expression of MMP2 and TIMP2 in 44 cases of RCCC and 20 cases of normal renal tissue were determined with immunohistochemical SAB assay.Of the 44 cases of RCCC,14 were at G 1,28 at G 2 and 2 at G 3 according to pathologic grading;and 24 cases were at pT 1,8 at pT 2 and 12 at pT 3 according to pathologic staging. Results The expression of MMP2 in RCCC was 79.6%(35/44),which was higher than that in normal renal tissue (15%, 3/20).The high expression of MMP2 was positively correlated with the grade and stage of RCCC (r=0.6316,P0.01;r =0.5096,P0.01,respectively).The expression of TIMP2 in RCCC was 100%(44/44),which was higher than that in normal renal tissue (35%,7/20);but its expression was not correlated with the stage and grade of RCCC (r=0.2404,P0.05;r=-0.1236,P0.05,respectively).The expression of MMP2 was not correlated with that of TIMP2 in RCCC (r=0.2015,P0.05). Conclusions MMP2 expression is positively correlated with the grade and stage of renal cancer, indicating that increased expression of MMP2 protein in RCCC is associated with poor prognosis of RCCC.By contrast,the abnormal expression of TIMP2 and its function of inhibiting tumor infiltration and migration need further investigation.MMP2 can be used as a useful molecular marker for prognosis of RCCC." @default.
- W2376350154 created "2016-06-24" @default.
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- W2376350154 date "2005-01-01" @default.
- W2376350154 modified "2023-09-27" @default.
- W2376350154 title "Expression and significance of matrix metalloproteinases2 and tissue inhibitors of metalloproteinases2 in renal clear cell carcinoma" @default.
- W2376350154 hasPublicationYear "2005" @default.
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