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- W2376365909 abstract "[Objective] To establish an animal model of BTT739 mice cured by a single dose of cyclophosphamide(CTX).[Methods] Mouse bladder carcinoma tissue was inoculated subcutaneously into BTT739 mice.7 days later,different doses of CTX were used intraperitoneally to treat these tumor-bearing mice.Tumor sizes and body weight were observed and recorded subsequently,and the minimal effective dose of CTX that could cure most of the tumor-bearing mice was found.Then another 12 tumor-bearing mice were randomly divided into two groups: the minimal effective dose of CTX was given intraperitoneally and the same volume of NS as control.The WBC count was measured at the 4th and 14th days after treatment.[Results] Inoculation of 2 mm3 bladder carcinoma tissue could make tumor cell progressive growth in T739 mice.The tumor sizes were 2～4 mm on day 7 after inoculation.Within 1 w after 15 ～ 400 mg/kg CTX treatment,the speed of tumor shrinkage and the side effects of tumor-bearing mice had a positive relationship with the dose of CTX used.2 months after CTX treatment,no mice was alive in 100～400 mg/kg CTX group;20% of mice were alive in 40 mg/kg CTX group;60% of mice were alive in 15 mg/kg CTX group.There was significantly difference between 15 mg/kg CTX group and control group(P0.01).On the 4th day after treatment,there was no significantly difference in peripheral blood WBC count in tumor-bearing mice between 15 mg/kg CTX group(11.36±0.30)×109/L and control group(11.14±2.14)×109/L(P0.05).The WBC count decreased to(8.46±0.76)×109/L in mice of CTX group on the 14th day after treatment.There was significantly difference in WBC count of the mice between the 4th and the 14th day after CTX treatment(P0.05);but there is no significantly difference compared with control group(9.86±3.40)×109/L(P0.05).[Conclusions] A single dose of CTX(15 mg/kg) had no obvious side effects,but could cure most of these tumor-bearing T739 mice.The animal model cured by a low dose of CTX(15 mg/kg) had been established successfully in BTT739 tumor-bearing mice." @default.
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- W2376365909 title "Experimental study on establishing mouse model of BTT739 tumor-bearing mice cured by a low dose of CTX" @default.
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