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- W2376368174 abstract "OBJECTIVE To study the pharmacokinetics of mifepristone vagina gel in rats and rabbits,and evaluate the feasibility of promote the drug concentration in target tissues by change the preparation.METHODS The mifepristone concentrations in the plasma were determined by HPLC and the pharmacokinetic parameters and related bioavailability were obtained by 3P97 software.The bioavailability of mifepristone gel and suspension in rabbits(25 mg·kg-1) were evaluated,and the drug concentration in plasma was compared with target tissue(uterus and ovaries) in rats compare treated with mifepristone gel(10 mg·kg-1).RESULTS The pharmacokinetic parameters of the test and reference preparation in rabbits were as follows: ρmax were 88.72 and 782.6 μg·L-1;tmax were 2.75 and 1.00 h;t1/2Ke were 20.38 and 4.148 h.The bioavailability of mifepristone gel was 89.31% of the suspension.The pharmacokinetic parameters of mifepristone gel in rat plasma,uterus and ovaries were as follows: ρmax were 171.5,1 009 and 914.2 μg·L-1.AUC0-48 were 945.0,553 6 and 1.558×104 μg·h·L-1.The DTE of mifepristone gel in uterus and ovaries were 3.570 and 12.99.CONCLUSION Compared with the mifepristone suspension,the prepared vagina gel raised the concentration and prolonged the resident time of the drug in the target tissues." @default.
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- W2376368174 date "2008-01-01" @default.
- W2376368174 modified "2023-09-24" @default.
- W2376368174 title "Pharmacokinetic Study of Mifepristone Vaginal Gel" @default.
- W2376368174 hasPublicationYear "2008" @default.
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