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- W2376370287 abstract "Objective To discuss patients with serrated lesions tissues MGMT gene methylation status and MGMT protein expression and cancer pathways and the role and clinical significance of MGMT gene in different age paragraph methylation level. Methods From 2007 to 2013 in the Military General Hospital of Beijing PLA, 225 cases of serrated lesions [96 cases of hyperplastic polyp(HP), 61 cases of sessile serrated adenoma/polyp(SSA/P) and 68 cases of traditional serrated adenoma(TSA)], 54 cases of tubular adenoma(TA), 69 cases of colorectal cancer(CRC) and 42 cases of normal colorectal mucosa tissues were selected; MGMT gene methylation status of CpG island was detected by qPCR applications Taqman probe(MethyLight) methods, methylation state of amplification target fragment was verified by by sequencing method, at the same time, MGMT protein expression in 116 cases of serrated lesions(including 52 cases of HP, 41 cases of SSA/P, 23 cases of TSA), 20 cases of TA, 24 cases of CRC, 24 cases of normal colorectal mucosa tissue was detected by immunohistochemical method. Results The differences of MGMT gene promoter methylation state and degree of abnormal MGMT protein positive degree in the serrated lesions and the control group were statistically significant(P 0.05), the negative correlation was found; the positive correlation was found between frequency of MGMT gene promoter methylation and different age paragraph, but the difference was not statistically significant(P 0.05). Conclusion Organization MGMT gene methylation may induce the protein expression in the main reason for the downgrade, it plays an important role in serrated canceration pathway of hyperplastic polyps-serrated adenoma-carcinoma." @default.
- W2376370287 created "2016-06-24" @default.
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- W2376370287 date "2014-01-01" @default.
- W2376370287 modified "2023-09-22" @default.
- W2376370287 title "Expression and significance of MGMT gene methylation status in colorectal serrated lesions" @default.
- W2376370287 hasPublicationYear "2014" @default.
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