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- W2376371122 abstract "Objective To investigate the protein expression of glucose transporter 1 (GLUT1) and vascular endothelial growth factor (VEGF) in clear cell renal cell carcinomas (RCC) and concomitant renal tissues. Methods Tumor tissues and corresponding peritumoral and macroscopically normal kidney tissues were collected from 60 patients with RCC.The expression of GLUT1 and VEGF was evaluated immuohistochemically in relation to clinic opathlogical characteristics.Western blot was also applied to confirm the differential protein levels of GLUT1 in tumoral and normal renal tissues. Results GLUT1 and VEGF protein expression was significantly higher in tumoral tissues than in peritumoral and normal tissues (P0.05,respectively).Stronger GLUT1 immunostaining was detected in larger tumors compared with that in smaller ones (P=0.033) and in advanced tumors compared with that in localized ones (P=0.085).Western blot showed a markedly increased GLUT1 protein content in cancerous samples than in normal ones,which was in accordance with the finding of immunohistochemistry. There were significant differences in VEGF expression in relation to tumor size and TNM stage (P=0.017,respectively).No significant difference was observed in either GLUT1 or VEGF expression between tumors of different nuclear grades. GLUT1 expression correlated positively with VEGF expression(r=0.307,P=0.017). Conclusions There are associations between the expression of GLUT1 and VEGF and the clinic opathlogical factors of clear cell RCC.Elevated levels of GLUT1 and VEGF may play a role in tumor growth and progression cooperatively." @default.
- W2376371122 created "2016-06-24" @default.
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- W2376371122 date "2009-01-01" @default.
- W2376371122 modified "2023-09-26" @default.
- W2376371122 title "Expression of GLUT1 and VEGF in renal cell carcinomas and their clinical significance meanings" @default.
- W2376371122 hasPublicationYear "2009" @default.
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