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- W2376381604 abstract "Objective To discuss the effect of Ozagrel sodium on content of ET and CGRP in Rats with Focal Cerebral Ischemia.Methods The improved Longa's method is adopted to makerat's cerebral artery embolism model(MCAO),and the radioimmunological assay method is employed to test the content of Endothelin(endothelin-1,ET-1) and Calcitonin gene related peptide in brain tissue. Results Ozagrel sodium can inhibit the excessive production of ET-1 in brain tissue and enhance the content of CGRP in brain tissue and rate of CGRP/ET-1 in brain tissue in the existence of dose-effect relationship. Conclusions Ozagrel sodium can protect rat's nerve injury caused by focal cerebral ischemia and,its mechanism may be related to the lowering the content of the rising ET-1 in Cerebral ischemia hindbrain tissue and increasing the CGRP in the cerebral tissue." @default.
- W2376381604 created "2016-06-24" @default.
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- W2376381604 date "2007-01-01" @default.
- W2376381604 modified "2023-09-24" @default.
- W2376381604 title "The Effect of Ozagrel Sodium on Content of ET and CGRP in Rats with Focal Cerebral Ischemia" @default.
- W2376381604 hasPublicationYear "2007" @default.
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