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- W2376382029 abstract "The aim of this study was to investigate the mediation mechanism of toll-like receptor 9(TLR9) and the related inflammatory factors in brain injury.Immunohistochemical ultra sensitive SP method was used to examine the dynamic expression of TLR9 and the related factors in the normal rats,injected with E.coli and HuangLianJieDu Decoction preventive rats in the present study.66 SD rats were randomly divided into three groups.The control group(n=6) was treated with normal saline by intraperitoneal injection.Experimental group(n= 30) was treated with E.coli culture by intraperitoneal injection 0.5 mL per rat(2.4×109 CFU· mL-1).HuangLianJieDu Decoction preventive groups(n=30) was treated with 12.6 mL·kg-1orally in advance 6 days,and then were intraperitoneally injected with 0.5 mL(2.4×109 CFU· mL-1) per rat E.coli culture.Each group was divided into 6 sub-groups and each of which has 5 rats.The rats of each experimental group,prevention group and one rat in control group were killed randomly at 3,6,9,12,18,24 hours after treated with E.coli.And then the expression of TLR9 and the related factors in brain were analyzed by immunohistochemistry.The results showed that there was a little amount of TLR9 expression in the brain under normal circumstances,while the TLR9 expression showed a significant change after E.coli infection,and it was more obvious over time.Compared with control group and prevention group,the expression of TLR9 increased significantly after 3 hours infected with E.coli,and it reached the peak after 12 hours(P0.01).There was no significant difference between prevention and control group(P0.05).These results indicated that the HuangLianJieDu Decoction can protect the brain injury by bacterial infection by suppressing the expression of TLR9." @default.
- W2376382029 created "2016-06-24" @default.
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- W2376382029 date "2012-01-01" @default.
- W2376382029 modified "2023-09-28" @default.
- W2376382029 title "Effects of HuangLianJieDu Decoction on the Expression of TLR9 in Brain Tissue of Rats Infected with Escherichia coli" @default.
- W2376382029 hasPublicationYear "2012" @default.
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