FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376385056> ?p ?o ?g. }

• W2376385056 abstract "OBJECTIVE Observe the change of TGFαand EGFR level in SCN,serum and tumor tissues of mice bearing breast cancer after elecreoacunpuncture for further discuss on the regulating mechanism of SCN output signal molecular of electroacupuncture on the spontaneous activity rhythm of animals bearing tumors.METHODS 18 male C57BL/6J mice were randomly divided into 3 groups with 6 in each group.LD domestication for 10 days,model establishment after DD domestication for 10 days and electroacupuncture after 7 days since model establishment succeed.Electroacupuncture on Changqiang(GV 1) and Baihui(GV 20) on CT4 with HANS Acupoint and Nerves Stimulator(HANS-200),2/15 Hz,0.5 mA,15 min for each time.Electroacupuncture for three times with one time everday.Animals were sacrificed after 2 hours in the third time.Extract the sample and detect the indexes by ELISA.RESULTS There was no significant differences in SCN TGFαlevel among 3 groups;In the serum and tumor tissues,the TGFαlevels of model group were higher significantly than blank group(P0.05) while there was no significantly difference between electroacupuncture group and model group.There was no significantly difference in SPZ EGFR level between model group and blank group.The EGFR levels of electroacupuncture group were higher significantly than model group(P0.05).In the serum and tumor tissues,the EGFR levels of model group were higher significantly than blank group(P0.05) while there was no significantly difference between electroacupuncture group and model group.In SCN and serum,the PK2 levels of electroacupuncture group were higher significantly than model group(P0.05) while there was no significantly difference between blank group and model group.CONCLUSION TGFα and EGFR levels in serum and tumor tissues of mice bearing breast cancer were significantly higher than normal mice.Electroacupuncture can decrease EGFR levels in SPZ and increase PK2 levels in SCN and serum of mice bearing breast cancer which suggested that electroacupuncture affect on the spontaneous activity rhythms probably through regulating PK2 levels in SCN and EGFR levels in SPZ which regulate TGFα levels indirectly.The effect on EGFR levels in SPZ of mice bearing tumors of electroacupuncture also suggested it play a part in the anti-tumor effect." @default.
• W2376385056 created "2016-06-24" @default.
• W2376385056 creator A5023564725 @default.
• W2376385056 date "2012-01-01" @default.
• W2376385056 modified "2023-09-26" @default.
• W2376385056 title "Influence of Electroacupuncture Changqiang(GV1)and Baihui(GV20) on SCN Output Signal Molecular of Mice Bearing Breast Cancer" @default.
• W2376385056 hasPublicationYear "2012" @default.
• W2376385056 type Work @default.
• W2376385056 sameAs 2376385056 @default.
• W2376385056 citedByCount "0" @default.
• W2376385056 crossrefType "journal-article" @default.
• W2376385056 hasAuthorship W2376385056A5023564725 @default.
• W2376385056 hasConcept C121608353 @default.
• W2376385056 hasConcept C126322002 @default.
• W2376385056 hasConcept C134018914 @default.
• W2376385056 hasConcept C142724271 @default.
• W2376385056 hasConcept C204787440 @default.
• W2376385056 hasConcept C2776202274 @default.
• W2376385056 hasConcept C2780678043 @default.
• W2376385056 hasConcept C3018023364 @default.
• W2376385056 hasConcept C530470458 @default.
• W2376385056 hasConcept C56837625 @default.
• W2376385056 hasConcept C71924100 @default.
• W2376385056 hasConceptScore W2376385056C121608353 @default.
• W2376385056 hasConceptScore W2376385056C126322002 @default.
• W2376385056 hasConceptScore W2376385056C134018914 @default.
• W2376385056 hasConceptScore W2376385056C142724271 @default.
• W2376385056 hasConceptScore W2376385056C204787440 @default.
• W2376385056 hasConceptScore W2376385056C2776202274 @default.
• W2376385056 hasConceptScore W2376385056C2780678043 @default.
• W2376385056 hasConceptScore W2376385056C3018023364 @default.
• W2376385056 hasConceptScore W2376385056C530470458 @default.
• W2376385056 hasConceptScore W2376385056C56837625 @default.
• W2376385056 hasConceptScore W2376385056C71924100 @default.
• W2376385056 hasLocation W23763850561 @default.
• W2376385056 hasOpenAccess W2376385056 @default.
• W2376385056 hasPrimaryLocation W23763850561 @default.
• W2376385056 hasRelatedWork W2349438810 @default.
• W2376385056 hasRelatedWork W2367276009 @default.
• W2376385056 hasRelatedWork W2367846925 @default.
• W2376385056 hasRelatedWork W2368450714 @default.
• W2376385056 hasRelatedWork W2368476771 @default.
• W2376385056 hasRelatedWork W2374583570 @default.
• W2376385056 hasRelatedWork W2378342600 @default.
• W2376385056 hasRelatedWork W2388778683 @default.
• W2376385056 hasRelatedWork W2388905814 @default.
• W2376385056 hasRelatedWork W2389631096 @default.
• W2376385056 hasRelatedWork W2391369175 @default.
• W2376385056 hasRelatedWork W2409798266 @default.
• W2376385056 hasRelatedWork W2410307779 @default.
• W2376385056 hasRelatedWork W2517897370 @default.
• W2376385056 hasRelatedWork W2706496976 @default.
• W2376385056 hasRelatedWork W2747163139 @default.
• W2376385056 hasRelatedWork W2980644489 @default.
• W2376385056 hasRelatedWork W3024409561 @default.
• W2376385056 hasRelatedWork W3131767439 @default.
• W2376385056 hasRelatedWork W656662890 @default.
• W2376385056 isParatext "false" @default.
• W2376385056 isRetracted "false" @default.
• W2376385056 magId "2376385056" @default.
• W2376385056 workType "article" @default.