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- W2376394467 abstract "Object:To investigate the differences of electrocardiogram(ECG) and morphological structure of cardiac tissue disturbed by ethanol extracts of white prepared lateral root of aconite(WPLRA) in healthy rats and kidney deficiency rats.Methods: Eighty male Sprague Dawley rats were divided randomly into healthy group and kidney deficiency model group,with forty rats in each group.Every group rats were respectively divided into four treatment groups at different intragastric administration dosages and blank control group,with eight rats in each group.Treatment group rats were administered ethanol extracts of white prepared lateral root of aconite(WPLRA),however blank control group corresponding normal saline,every day for two weeks.All rats Ⅱ couplet electrocardiogram were traced,heartbeat rate(BPM) and peak-to-peak(P-P) as well as arrhythmia were recorded.Besides,all rats histopathological changes of cardiac was observed by HE.Results: WPLRA made healthy and model rats' heartbeat rate accelerate.Higher dose,faster heartbeat rate.But accelerating extent of model rats was smaller than that of normal rats.WPLRA caused healthy and model rats' P-P value increase and both increasing extent was consistent with adding dose.WPLRA also led to arrhythmia and higher dose WPLRA caused more serious arrhythmia and higher occurring rate of arrhythmia.In addition,in same dose,the occurring rate of arrhythmia of model rats was lower than that of healthy rats.WPLRA caused cardiac histopathological changes of both healthy rats and model rats.Cardiac pathological damage became more and more serious gradually with adding dose.And in same dose administration,the cardiac pathological damage of model rats was slighter than that of normal rats.Conclusion: There is the dose-related feature on cardiac toxicity of WPLRA.The cardiac toxicity was relative to physiological status.The same dosage WPLRA could rouse a weaker cardiac toxicity in kidney deficiency rats than that in healthy rats." @default.
- W2376394467 created "2016-06-24" @default.
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- W2376394467 date "2011-01-01" @default.
- W2376394467 modified "2023-09-24" @default.
- W2376394467 title "Comparative study on effect of white prepared lateral root of aconite on electrocardiogram and morphological structure of cardiac tissue between healthy and kidney deficiency rats" @default.
- W2376394467 hasPublicationYear "2011" @default.
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