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- W2376395768 abstract "Objective: To investigate the effects of n-butanol extract and total alkaloids of Sarcococca ruscifolia Stapf,a traditional Chinese medicine,on smooth muscles of gastro-intestines in rats and guinea pigs,and on chemical gastric ulcer in mice.Method: The isolated ileum segment from guinea pigs,strips of gastric fundus and duodenum muscles from rats were prepared,then the contraction intensity and frequency of the smooth muscles were measured.The distance that the active charcoal powder in intestines of mice was carried forward was determined.The gastric ulcer was induced by hydrochloric acid plus alcohol in mice.Results: N-butanol extract and total alkaloids of S.ruscifolia Stapf concentration-dependently reinforced the contraction intensity of isolated ileum muscles in guinea pigs and gastric fundus muscles in rats,with EC_(50) values of 9.9×10~(-6),7.3×10~(-6),1.65×10~(-5) and 4.3×10~(-6)g/L,respectively.Moreover,the total alkaloids markedly increased the amplitude of spontaneous contraction in duodenum of rats,but did not increase the frequency of contraction.Whereas,then-butanol extract had no significant effect on both amplitude and frequency of contraction in duodenum.In vivo,n-butanol extract and total alkaloids of S.ruscifolia Stapf significantly accelerated the intestinal propulsion,and had no protection of gastric ulcer induced by hydrochloric acid plus alcohol.Conclusion: N-butanol extract and total alkaloids of S.ruscifolia Stapf have the gastro-intestines kinesics-like actions.Steroidal alkaloids in S.ruscifolia Stapf may be the major active components." @default.
- W2376395768 created "2016-06-24" @default.
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- W2376395768 date "2005-01-01" @default.
- W2376395768 modified "2023-09-22" @default.
- W2376395768 title "Effects of Extracts of Sarcococca Ruscifolia Stapf on Gastro-intestines Function in Vitro and in Vivo" @default.
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