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- W2376396973 abstract "Objective To explore the incidence of IgH gene rearrangement in B-cell acute lymphoblastic leukemia(B-ALL) and to analyze its clinical and other cytogenetic features.Methods One hundred and fifty-eight newly diagnosed B-ALL patients were enroled in this study.Conventional R-banding assay was used for karyotypic analysis.Fuorescence in situ hybridization(FISH ) was performed to analyze the IgH gene rearrangement.Results IgH gene rearrangements were found in 6.9%patients,and the percentage of IgH gene rearrangement positive cells ranging from 10.5%to 88.2%.Among 11 B-ALL cases with IgH rearrangements showed by FISH analysis,2 cases presented normal karyotype.In 9 cases with chromosomal abnormalities,complex karyotype was detected in 8 cases and rearrangements involving 14q32 were found in 5 cases.The incidence of IgH gene rearrangement in those cases with complex chormosome abnormalities was higher than that in the normal karyotype and non-complex chromosome abnormalities(14.5%vs3.8%vs 1.9%,P0.05).Conclusion The IgH gene rearrangement is a recurrent cytogenetic abnormality in B-ALL.FISH analysis plays an important role in identifying the rearrangements involving the IgH gene." @default.
- W2376396973 created "2016-06-24" @default.
- W2376396973 creator A5073422797 @default.
- W2376396973 date "2011-01-01" @default.
- W2376396973 modified "2023-09-25" @default.
- W2376396973 title "Detection of IgH Gene Rearrangement in B-cell Acute Lymphoblastic Leukemia by Dual-color Fluorescence in Situ Hybridization" @default.
- W2376396973 hasPublicationYear "2011" @default.
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