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- W2376423422 abstract "AIM: To investigate the effects of imidazoline-I 1-rec eptor agonist Mox onidine on heart rate variability (HRV) and insulin sensitivity in patients wi th essential hypertension (EH). METHODS: 22 patients with mild to moderate EH w ere enrolled. A withdrawal period of 1~2 weeks was followed by 4 weeks of Moxon i dine treatment (0.2~0.4 mg/d). Before and after the treatment, ambulatory 24- ho ur holter monitor records were obtained in all patients. We calculated the HRV o f each record. At the same time, we measured fasting plasma glucose (FPG) and fasting insulin (FINS) levels and the insulin sensitivity index (ISI). RESULTS: After Moxonidine treatment, blood pressure in EH patients w as lowered sig nificantly as compared with that before ( P 0.01). In all patients, SDNNI w as lowe red significantly ( P 0.01), SDNN and SDANNI were increased significantly ( P 0 .01), rMSSD and pNN 50 were increased, but not significantly ( P 0.05 ). In the patients with impaired glucose tolerance (EH+IGT), the FPG was lowered, but no t significantly ( P 0.05). FINS was lowered and ISI was increased, very significantly ( P 0.01). But no significant changes were found in pati ents with normal glucose tolerance (EH+NGT). CONCLUSION: Moxon idine can decrease bl ood pressure, improve HRV in patients with EH and has beneficial effect on i mproving insulin sensitivity in EH patients with impaired glucose tolerance, but not in patients with normal glucose tolerance." @default.
- W2376423422 created "2016-06-24" @default.
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- W2376423422 date "2003-01-01" @default.
- W2376423422 modified "2023-09-23" @default.
- W2376423422 title "The effects of Moxonidine on heart rate variability and insulin sensitivity in hypertensive patients" @default.
- W2376423422 hasPublicationYear "2003" @default.
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