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- W2376431336 abstract "AIM To determine the body distribution of nanoparticle associated adriamycin (NADM) after administration into the hepatic artery of rats, and to compare it with that of free adriamycin (FADM). METHODS 24 male SD rats were divided into two groups at random, with 12 rats in each. NADM and FADM were injected into the hepatic artery of animals. The dose of adriamycin in each formulation was 2 mg·kg -1 body weight, and the concentration was 1.0 mg·mL -1 . At 1, 5, and 15 h after drug administration, 4 animals in each group were sacrificed and the adriamycin concentrations in the plasma, liver, heart, spleen, lungs, and kidneys were determined using a reverse phased high performance liquid chromatography with fluorescence detector (RP HPLC) technique. RESULTS NADM drastically increased the adriamycin concentrations in the liver and spleen of rats at 1, 5, and 15 h post injection, as compared to FADM, whereas the concentrations in the plasma, lungs, and kidneys decreased. Compared with those in NADM rats, relatively higher concentrations were found in the heart of FADM rats 1 and 5 h post injection but lower 15 h post injection. CONCLUSION The body distribution of adriamycin can be modified when it is encapsulated in nanoparticles and administered into the hepatic artery. Higher concentration of the drug is in the liver and spleen, whereas the concentration in the heart, plasma, kidneys, lungs is relatively lower." @default.
- W2376431336 created "2016-06-24" @default.
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- W2376431336 date "2000-01-01" @default.
- W2376431336 modified "2023-09-27" @default.
- W2376431336 title "Early dynamical body distribution of nanoparticle associated adriamycin after administration into the hepatic artery of rats determined with HPLC technique" @default.
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