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- W2376452499 abstract "ADP is found to be the potent substance inducing the platelet aggregation in the early time in vivo and it plays a key role in the formation of coagulation clot and pathological arterial thrombus.The platelet aggregation induced by ADP starts by the changing of platelet morphology or the decrease of cAMP level after ADP combines with the ADP receptor.However compared with thrombin and collagen,ADP is a weak platelet agonist alone.In addition,ADP is considered as co-factor of the platelet activation for if can enhance or magnify the effects of other agonists.ADP receptor antagonists inhibit the expression,combination and the activity of the ADP receptor and thus repress the aggregation of the platelet,which is very important to the treatment of the thrombosis.Now,because of their valid antithrombotic activity and safety,the ADP receptor antagonists are widely used as clinical drugs.In this article we summarize the types of the platelet ADP receptor and several crucial receptor antagonists and provide valuable references to the research and development of these drugs." @default.
- W2376452499 created "2016-06-24" @default.
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- W2376452499 date "2010-01-01" @default.
- W2376452499 modified "2023-09-25" @default.
- W2376452499 title "Advances in Research of ADP Receptors and Antagonists of Platelets" @default.
- W2376452499 hasPublicationYear "2010" @default.
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