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• W2376455770 abstract "Somatostatin, the hypothalamic growth hormone release inhibitory factor (GHRIF), directly inhibits both the first and second phases of insulin secretion. The sensitivities of these two phases of insulin secretion to somatostatin differ remarkably. The first phase of secretion is approximately 25 to 50 times more sensitive to somatostatin inhibition than is the second phase. In addition, somatostatin inhibition of insulin secretion during the second phase is by supplemental calcium, whereas the somatostatin effect on the first phase is unaffected by additional calcium. These findings suggest that the cellular events which produce the two phases of insulin secretion are separate processes, and that somatostatin has a dual mechanism of action in inhibiting insulin secretion. Insulin secretion, both in vitro and in vivo, in response to a sustained glucose stimulus is characterized by a diphasic response (1). This diphasic response consists of an initial rapid secretory phase followed by a decline in rate of secretion and then a slowly rising secretion rate. Somatostatin (GHRIF) has been shown to inhibit both the first and second phases of insulin secretion (2-4). A dose-response relationship for somatostatin inhibition of the second phase has been demonstrated (3), but no such dose-response relationship has been shown for somatostatin inhibition of the first phase. The relative sensitivities of these two phases to somatostatin inhibition have not been studied. Calcium ion (Ca2+) is essential for insulin secretion (5), as it is for many other secretory processes (6). Increasing Ca2+ concentration increases the amount of insulin released in response to a glucose stimulus during both the first and second phases of secretion by the isolated perfused rat pancreas (1, 5). Somatostatin inhibition of insulin secretion during the second phase is reversed by elevating the Ca2+ concentration (7). Whether elevation of the Ca2+ concentration will antagonize somatostatin inhibition of the first phase has not been reported. The purpose of this paper is to report a marked difference in the somatostatin concentration required for inhibition of these two phases of secretion and also to report that the ability of an elevated Ca2+ concentration to reverse the somatostatin inhibition of these two phases is strikingly different." @default.
• W2376455770 created "2016-06-24" @default.
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• W2376455770 date "2016-01-01" @default.
• W2376455770 modified "2023-09-26" @default.
• W2376455770 title "Does somatostatin inhibition of insi mechanisms of action" @default.
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